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Anger, Isolation, and Substance Use: How Depression Can Affect Men Differently

Jun 03, 2025
Anger, Isolation, and Substance Use: How Depression Can Affect Men Differently
How do you know if a man is depressed? It’s hard to tell because the symptoms aren’t always the typical symptoms of sadness and low energy. Here’s how to spot male depression and what to do about it.

When you think of depression, the symptoms that likely come to mind are sadness, low energy, or a persistent feeling of hopelessness. But for many men, depression manifests in ways that are less stereotypical and, often, harder to recognize.

At Holistic Behavioral & TMS Therapy, with offices in Aurora and Chicago, Illinois, and Las Vegas, Nevada, Babatunde Ogundipe, MD, and our team understands that men experience depression differently, often with unique challenges that require specialized care.

During this Men’s Health Month, we’re shedding light on how male depression differs from depression in women, what causes it, how it manifests, and what steps men can take to regain control of their mental health.

Why does male depression differ?

Depression doesn’t discriminate when it comes to gender, but biological, social, and cultural factors often influence the way it presents. Biologically, men and women experience depression differently due to hormonal and neurological differences.

However, societal norms play a significant role as well. 

Many men grow up learning to suppress their emotions or equate vulnerability with weakness. This can create a pattern where feelings of sadness or despair are redirected into other, more “acceptable” outlets, such as anger or risk-taking behaviors. These factors often delay diagnosis and treatment or mask the condition altogether.

Common causes of male depression

While common triggers of depression apply to men and women alike, certain factors disproportionately affect men, such as:

Work-related stress

Men often tie their identity and value to their professional success. Job insecurity or financial strain can amplify feelings of inadequacy.

Relationship challenges

Divorce, separation, or a strained relationship can hit men particularly hard, as many rely on their partners as their primary emotional outlet.

Physical health concerns

Chronic illnesses like heart disease or diabetes not only worsen depression but may also lead to feelings of helplessness.

Life transitions

Becoming a father, retiring, or suffering the loss of a loved one can contribute to an overwhelming emotional burden.

Pressure to conform

Societal expectations around masculinity often make it difficult for men to discuss emotional struggles or seek help.

Recognizing the symptoms in men

While sadness and low energy are common indicators of depression, men often exhibit different symptoms, which can make it harder to identify the condition. Key signs in men include:

Anger and irritability 

These are two of the most overlooked symptoms of male depression. Instead of openly expressing sadness, many men may lash out at friends and family or experience frequent frustration over minor setbacks.

Substance use 

Men are more likely to use alcohol or drugs as a form of self-medication to cope with their feelings, which can create a dangerous cycle, worsening the depression over time.

Isolation 

Men dealing with depression may pull back from their loved ones or stop participating in activities they once enjoyed. This withdrawal often exacerbates existing feelings of loneliness.

Risk-taking behavior 

Depression can lead to impulsive or risky decisions, including reckless driving, gambling, or unsafe sexual activities. These behaviors often serve as a distraction from internal struggles.

Physical symptoms 

Men with depression might also experience frequent headaches, muscle pain, digestive problems, or other unexplained physical ailments.

If you notice that you or someone you care about exhibits several of these symptoms, call us.

How men can take actionable steps

Recognizing the need for help is often the most challenging step for men facing depression. Once they get past that hurdle, however, they can regain control by taking a few critical steps:

Talk it out 

Opening up to a friend or trusted family member can alleviate some of the emotional weight. Starting the conversation, even if it feels difficult, is often a major step toward healing. 

Seek professional help 

Therapy is a tried-and-true way to unravel emotional struggles, set goals, and develop coping mechanisms. At Holistic Behavioral & TMS Therapy, we offer a range of services, including psychotherapy and group therapy

Explore innovative treatments 

If you still feel stuck after trying traditional approaches, our advanced treatments like transcranial magnetic stimulation (TMS) or Spravato® therapy can provide new hope. These solutions, both available at Holistic Behavioral & TMS Therapy, offer cutting-edge methods for addressing even treatment-resistant depression.

If you or a loved one is showing signs of male depression, professional treatment can make all the difference. Call Holistic Behavioral & TMS Therapy or book online today.